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2026 Week 1 NFL score predictions, best picks today: Expert reveals exact scores for every NFL game
SportsLine expert Eric Cohen reveals his score predictions for every game on the Week 1 NFL schedule
22h
NFL Week 1 Opening Odds for Every Game (Line Movement in 49ers vs. Rams, Packers vs. Vikings, More)
Week 1 is finally here! The NFL season opens up on Wednesday night with the New England Patriots and Seattle Seahawks squaring off in a Super Bowl rematch, one
After months of pre-draft predictions, free-agency frenzy, draft-day surprises, OTAs, minicamps, training camp and the preseason, it's time to play NFL games that count.
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on betting sites on top-rated NFL picks since its inception. The model enters the 2026 NFL season on a 53-37 run on top-rated picks dating back to 2024. Anybody following its picks at NFL betting sites could have seen strong returns.
In Sporting News' first picks and predictions against the spread for the 2026 NFL regular season, the Seahawks and Rams get off to great starts as co-favorites in the NFC West, while the Giants and Eagles win in their opening NFC East matchups.